An interaction between NDE1 and high birth weight increases schizophrenia susceptibility

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An interaction between NDE1 and high birth weight increases schizophrenia susceptibility

Pre- and perinatal environmental factors have been shown to increase schizophrenia risk particularly when combined with genetic liability. The investigation of specific gene environment interactions in the etiology of psychiatric disorders has gained momentum. We used multivariate GEE regression modeling to investigate the interaction between genes of the DISC1 pathway and birth weight, in rela...

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Renal injury due to ischemia-reperfusion (I/R) is the major cause of acute kidney injury. Whether enhanced susceptibility to renal injury due to I/R can be programmed during fetal life is unknown. Epidemiological studies indicate that low birth weight (LBW) individuals are more susceptible to renal injury than normal birth weight (NBW) individuals. Thus, the aim of this study was to test the hy...

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ژورنال

عنوان ژورنال: Psychiatry Research

سال: 2015

ISSN: 0165-1781

DOI: 10.1016/j.psychres.2015.08.038